博士招生芬兰奥卢大学招收生物化学结
Projectdescription
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Ourteamfocusesonstructure,functionandselectiveinhibitionofproteinsinvolvedinsignalingthroughADP-ribosylation–aposttranslationalmodificationaffectingproteinstability,function,andinteractionsinmultiplecellularpathways.Wedevelopassayssuitableforhigh-throughputscreeningofinhibitorsandusestructuralinformationformorerationaldesigntodevelopspecificinhibitorsthatcanbeusedaschemicalprobestostudythefunctionsoftheproteinsand,insomecases,tovalidatethemasdrugtargets.ProteinX-raycrystallographyisourmaintoolusedtounderstandstructure-activityrelationshipsof
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